Lipid Droplets and Cellular Lipid Metabolism
نویسندگان
چکیده
منابع مشابه
Lipid droplets and cellular lipid metabolism.
Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism. In addition, LDs are implicated in a number of other cellular functions, ranging from protein storage and degradation to viral replication. These p...
متن کاملSpastin Binds to Lipid Droplets and Affects Lipid Metabolism
Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is a conserved microtubule (MT)-severing protein, involved in processes requiring rearrangement of the cytoskeleton in c...
متن کاملMuscle Lipid Metabolism: Role of Lipid Droplets and Perilipins
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) availability. Skeletal muscle is an extremely complex tissue: its metabolic capacity depends on the type of fibers it is made up of and the level of stimulation it undergoes, such as acute or chronic contraction. Ob...
متن کاملLipid Droplets and Phospholipid Metabolism in Macrophages
What you have in this slide (Slide 3) is a monocyte-derived human macrophage [1], stained in blue with a protein of lipid metabolism called lipin-1, which localizes on the surface of these huge cytoplasmic formations that tend to distribute in the periphery of the cells. These formations are lipid droplets and, as you can see, macrophages have many of them. If we take a closer look at one of th...
متن کاملLipid droplets
OK, they are cute, but why should a developmental biologist care about them? Onset of calcification early in ontogeny coupled with gradual, progressive morphological development permits the recognition of growth sequences for over a hundred trilobite species. Striking variation in the number of trunk segments at maturity across ontogeny and phylogeny, coupled with the curious pattern of segment...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 2012
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev-biochem-061009-102430